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Hyperthyroidism
Last updated October 2004
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Hyperthyroidism And Pregnancy

About 1 in 500 women have hyperthyroidism during pregnancy. In some, it is a preexisting condition; in others, the condition will develop during the course of the pregnancy. It can be difficult to diagnose because the pregnancy often "masks" it; that is, some of the symptoms may be attributed to the pregnancy itself rather than to hyperthyroidism.

  • Hyperthyroidism may affect a woman's ability to become pregnant.

  • The most common cause of hyperthyroidism in pregnancy is Graves' disease   The most common form of hyperthyroidism or high levels of circulating thyroid hormone.  Graves' disease is an autoimmune disorder of the thyroid gland that causes excessive production and release of thyroid hormone.  Hyperthyroid eye and skin changes are sometimes associated with this condition..

  • Symptoms generally will be worse in the first half of the pregnancy, will lessen during the second half, and most likely will recur after the baby is born.

  • You should continue with your normal anti-thyroid medication during your pregnancy as prescribed by your doctor.

  • Most pregnant women and their babies will not experience significant problems if the hyperthyroidism is mild to moderate. If properly treated the pregnancy can be expected to progress normally.

  • Women with severe or uncontrolled hyperthyroidism have an increase risk of infection, iron deficiency (anemia), and high blood pressure accompanied by too much protein in the urine (a potentially dangerous condition called pre-eclampsia).

  • If a woman has severe hyperthyroidism, her baby has a chance of having hyperthyroidism as well. There is a risk to the outcome of the pregnancy, having a small baby or a premature birth.

Fortunately, most women who have hyperthyroidism in pregnancy can be successfully treated with medication. The anti-thyroid drug   Any one of several chemical agents that interfere and hinder the production of thyroid hormone. Examples are propylthiouracil (PTU), methimazole (Tapazole), and carbimazole. Propylthiouracil is commonly prescribed and can be safely used during pregnancy. It may take up to a month on medication for the symptoms to resolve. Radioactive iodine   Iodine that contains a radioactive component.  This element is chemically depicted as 131I.  This form of iodine, which puts out intense energy, is used in a special test to diagnose thyroid disease. cannot be used during pregnancy. Rarely, if the symptoms and thyroid hormone   A chemical substance produced by the thyroid gland and released into the bloodstream. It interacts with almost all body cells, causing them to increase their metabolic activity. Two forms of thyroid hormone, abbreviated as T3 and T4, are found in bloodstream. levels cannot be controlled, surgery needs to be considered to remove the thyroid gland   A small, butterfly-shaped endocrine organ located in the neck below and in front of the Adam's apple. The thyroid gland weighs about 20 to 25 grams and produces thyroid hormone, which is released into the bloodstream..

Hyperthyroidism does not affect labor and delivery. However, thyroid storm can develop which can be life threatening. The symptoms are an exaggeration of the normal hyperthyroid symptoms with a very fast heart rate, tremors, nervousness, altered consciousness, nausea, vomiting, diarrhea, and an extremely high fever. This will require intensive care treatment to try normalizing the very high thyroid hormone levels and keeping the patient cool.

Following delivery, anti-thyroid treatment must continue. Although both the anti-thyroid drugs Propylthiouracil and methimazole do pass into the breast milk, both can be used safely in breast-feeding women. You should discuss this with your physician.

Your baby will be thoroughly checked to be sure he or she is well with no evidence of thyroid problems. Most babies born to hyperthyroid mothers whose hyperthyroidism has been well controlled during pregnancy are normal healthy babies.

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